Prenatal Placental and Postnatal Mammary Programming of Cardiovascular and Renal Diseases

Grant number: 400003

Abstract

Being born small and the associated catch-up growth, independently predict adult hypertension. Reduced placental blood flow is a major cause of fetal growth restriction and is implicated in programming adult disease. We are the first to demonstrate that placental compromise in rats also adversely affects breast development, milk quality and supply, which further impair growth during lactation. This is followed by accelerated growth after weaning, programming more adverse outcomes. Using a rat model, we will determine for the first time if restricted nutrition before birth via the placenta or after birth via lactation increases the risk of developing high blood pressue and kidney and blood ve..

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Related publications (5)

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Reducing pup litter size alters early postnatal calcium homeostasis and programs adverse adult cardiovascular and bone health in male rats

JF Briffa, R O’dowd, T Romano, BS Muhlhausler, KM Moritz, ME Wlodek

2019-01-01

The in utero and early postnatal environments play essential roles in offspring growth and development. Standardizing or reducing ..

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Uteroplacental insufficiency temporally exacerbates salt-induced hypertension associated with a reduced natriuretic response in male rat offspring

LA Gallo, SL Walton, MQ Mazzuca, M Tare, HC Parkington, ME Wlodek, KM Moritz

2018-12-01

Key points: Low weight at birth increases the risk of developing chronic diseases in adulthood A diet that is high in salt is know..

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Uteroplacental insufficiency in rats induces renal apoptosis and delays nephrogenesis completion

JSM Cuffe, JF Briffa, S Rosser, AL Siebel, T Romano, DH Hryciw, ME Wlodek, KM Moritz

2018-03-01

Aim: Uteroplacental insufficiency in rats reduces nephron endowment, leptin concentrations and programmes cardiorenal disease in o..

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Uteroplacental insufficiency reduces rat plasma leptin concentrations and alters placental leptin transporters: ameliorated with enhanced milk intake and nutrition

JF Briffa, R O'Dowd, KM Moritz, T Romano, LR Jedwab, AJ McAinch, DH Hryciw, ME Wlodek

2017-06-01

Key points: Uteroplacental insufficiency compromises maternal mammary development, milk production and pup organ development; this..

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Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and Heart Failure

FZ Marques, PR Prestes, SG Byars, SC Ritchie, P Würtz, SK Patel, SA Booth, I Rana, Y Minoda, SP Berzins, CL Curl, JR Bell, B Wai, PM Srivastava, AJ Kangas, P Soininen, S Ruohonen, M Kähönen, T Lehtimäki, E Raitoharju

2017-01-01

Background-—Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammato..

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